December 7, 2022

Entering the Week 5 NFL schedule, 30 teams have already played at least one divisional game. The last two will get into the action on Sunday when the Jets play their first AFC East game against the Dolphins and the Ravens play their first AFC North contest versus the Bengals. Baltimore is a 3-point favorite in the latest Week 5 NFL odds from Caesars Sportsbook, one of the tightest NFL spreads of the week. Still, Joe Burrow and the Bengals swept last year’s season series, hanging 41 points on Baltimore in each game.

The Jets are 3.5-point underdogs in the NFL Vegas odds, even with Teddy Bridgewater expected to start in place of Tua Tagovailoa (concussion) for Miami. New York has lost four straight to Miami and eight of the last nine meetings. Should that recent history affect your Week 5 NFL bets? All of the Week 5 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 5 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 5 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 5 NFL predictions

One of the model’s strongest Week 5 NFL picks is that the Titans (-2.5) cover against the Commanders in almost 60% of simulations. Tennessee (2-2) has won outright and covered in its last two games, while Washington (1-3) is going in the opposite direction. The Commanders won and covered in their season-opener, but have lost straight-up and against the spread in their last three games.

Washington’s offense is in shambles, as Carson Wentz leads the NFL in interceptions (five) and sacks taken (17). The defense isn’t any better, as the Commanders have the fewest takeaways in the league (one), while ranking in the bottom 10 in points allowed and yards allowed. Tennessee is rounding into form behind Derrick Henry’s resurgence, as the two-time rushing champ has 290 total yards and two scores over his last two games. The model has Henry having another 100-yard game of total offense.

Another one of its Week 5 NFL predictions: The Jaguars (-7) cover at home in a divisional matchup against the Texans. Jacksonville has played just one home game thus far, a 24-point shutout win over the Colts. Jacksonville ranks third with a plus-38 point differential, trailing only arguably the top two teams in the NFL, the Bills and Eagles.

The Jags fell to Philly in Week 4 thanks to wet conditions that resulted in four lost fumbles by Trevor Lawrence. That was certainly an outlier of a game since Lawrence had just three combined lost fumbles over his previous 17 games. The Jags have a top-10 offense and a top-10 defense, while Houston is in the bottom half of the league in both categories. Jacksonville is projected to win by double-digits and to cover in well over 50% of simulations. The model also has the Under (44.5) hitting well over 50 percent of the time. See which other teams to pick here.

How to make Week 5 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule, and it also says an underdog delivers a huge upset. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which underdog delivers a huge upset? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,000 since its inception, and find out.

Week 5 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Thursday, Oct. 6

Colts at Broncos (-3, 43.5)

Featured Game | Denver Broncos vs. Indianapolis Colts

Sunday, Oct. 9

Giants at Packers (-8, 41.5)

Featured Game | Green Bay Packers vs. New York Giants

Steelers at Bills (-14, 47)

Featured Game | Buffalo Bills vs. Pittsburgh Steelers

Chargers at Browns (+3, 48.5)

Featured Game | Cleveland Browns vs. Los Angeles Chargers

Texans at Jaguars (-7, 44.5)

Featured Game | Jacksonville Jaguars vs. Houston Texans

Bears at Vikings (-7, 43)

Featured Game | Minnesota Vikings vs. Chicago Bears

Lions at Patriots (-3, 47)

Featured Game | New England Patriots vs. Detroit Lions

Seahawks at Saints (-4, 45)

Featured Game | New Orleans Saints vs. Seattle Seahawks

Dolphins at Jets (+3.5, 44.5)

Featured Game | New York Jets vs. Miami Dolphins

Falcons at Buccaneers (-6.5, 45.5)

Featured Game | Tampa Bay Buccaneers vs. Atlanta Falcons

Titans at Commanders (+2.5, 42)

Featured Game | Washington Commanders vs. Tennessee Titans

49ers at Panthers (+5, 39.5)

Featured Game | Carolina Panthers vs. San Francisco 49ers

Eagles at Cardinals (+5, 49.5)

Featured Game | Arizona Cardinals vs. Philadelphia Eagles

Cowboys at Rams (-4.5, 45.5)

Featured Game | Los Angeles Rams vs. Dallas Cowboys

Bengals at Ravens (-3, 48)

Featured Game | Baltimore Ravens vs. Cincinnati Bengals

Monday, Oct. 10

Raiders at Chiefs (-7, 53)

Featured Game | Kansas City Chiefs vs. Las Vegas Raiders

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