Video shared on social media showed Fraser looking teary eyed as the audience applauded.
Directed by Darren Aronofsky, the film focuses on Fraser’s character, Charlie, a reclusive 600-pound man trying to reconnect with his estranged daughter.
“Stranger Things” actress Sadie Sink plays his daughter.
“The Mummy” star is being touted as a serious Oscars contender with his portrayal in the drama.
“I developed muscles I did not know I had,” Fraser said.